Cerebral Venous Thrombosis (CVT) following COVID-19 vaccination: an umbrella review of systematic reviews

Authors

  • Fatemeh Sadeghi-Ghyassi Health Information Management, Faculty of Management & Medical Informatics, Tabriz University of Medical Science, Tabriz, Iran.
  • Gholamreza Faridaalaee Emergency and trauma care research center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hanieh Salehi-Pourmehr Research center for Evidence Based-Medicine, Iranian EBM Center: A Joanna Briggs Institute Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hasan Soleimanpour Emergency and trauma care research center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Kavous Shahsavarinia 1- Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2- Emergency and trauma care research center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Nasrin Abolhasanpour Research center for Evidence-Based Medicine, Iranian EBM Center: A Joanna Briggs Institute Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sanam Atashgahi Emergency and trauma care research center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:

Background and Objective: This umbrella review presents comprehensive data on the evidence of the association between cerebral venous thrombosis (CVT) and COVID-19 vaccinations. Methods: We searched related databases to access issue-related systematic reviews both with meta‐analyses or without it that studied the connotation between COVID 19 vaccination and CVT in any languages from initiation of March 1, 2022. Two reviewers independently extracted the data using the JBI Form for Data Extraction in Systematic Reviews and Research Syntheses. Results: The primary search resulted in 886 titles, and finally, 48 full texts were selected, and of these, 12 qualitative systematic reviews or quantitative meta-analyses were eligible for the umbrella review. No study was excluded based on using the JBI checklist for critical appraisal. The results revealed that cerebral venous sinus thrombosis (CVST) from the COVID-19 vaccine could occur in any age group, in both sexes, and with all types of vaccine. However, young females were the predominantly affected cases. Although more common in adenovirus vaccine types, vaccines consisting of mRNA are not free from side effects. Headache was the most typical clinical symptom. Thrombocytopenia, PF4 IgG Assay, and d-Dimer evaluation were positive in many reported studies. Conclusion: The results showed that CVST from the COVID-19 vaccine can happen without age limitation for both sexes and all vaccine types. Although CVST is a life-threatening condition, early diagnosis and, most importantly, its management can be life-saving for patients. The overall balance of risk and benefit in favor of vaccination is positive in all of the included studies in the current umbrella review.  

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

An Introduction to Umbrella Reviews

سخن سردبیر Editorial مجله دانشگاه علوم پزشکی رفسنجان دوره هجدهم، مهر 1398، 622-621     درآمدی بر مرور چتری An Introduction to Umbrella Reviews   محسن رضائیان[1]   M. Rezaeian   آیونیدیس (Ioannidis) در سال 2009 میلادی توضیح روشنی از مرور چتری (Umbrella review) ارائه کرده است. وی توضیح می‌دهد که یک مرور چتری به طور نظام‌مند به جمع‌بندی و ارزشیابی نتایج حاصل از چندین مرور نظام‌مند و ی...

full text

Systematic reviews of psychosocial interventions for autism: an umbrella review.

AIM A wide range of psychosocial interventions for the treatment of individuals with autism-spectrum disorders (ASDs) have been evaluated in systematic reviews. We conducted an umbrella review of systematic reviews of the effectiveness of psychosocial interventions for ASD. METHOD Comprehensive searches were conducted in 25 bibliographic databases, relevant journals and reference lists up to ...

full text

Evaluation of cerebral venous thrombosis risk following oral contraceptive use: A case report and update.

Background and Objectives: The aim of the present study was to report a case of cerebral venous thrombosis (CVT) folowing consumption of the oral contraceptive pills with high estrogen levels. Case Report: A 35-year-old woman presenting a headache was diagnosed with thrombosis in the upper sagittal, sigmoid and transverse  veins, by CT SCAN, MRI and MRV of the brain. Conclusion: The chance ...

full text

Declining mortality in cerebral venous thrombosis: a systematic review.

BACKGROUND AND PURPOSE Cerebral venous thrombosis (CVT) is nowadays considered a disease with a good outcome in most cases, but in the past, these patients were thought to have a grave prognosis. We systematically studied the apparent decline in mortality of patients with CVT over time. METHODS A systematic review of the literature (MEDLINE and EMBASE) was performed. Studies with ≥40 patients...

full text

Cerebral Venous Thrombosis Following Varicella Infection.

1 male was brought to the hospital with severe headache, vomiting and seizures. The illness started with profuse rash predominantly on the trunk, limbs and also on the face two weeks back. The lesions were centripetal and were diagnosed to be chicken pox. The lesions were in crusting stage when the patient developed neurological complaints. His symptoms started with sudden onset of headache whi...

full text

Cerebral venous thrombosis: an update.

Cerebral venous thrombosis (CVT) is a rare type of cerebrovascular disease that can occur at any age, including in neonates, and it accounts for 0.5% of all stroke. The widespread use of neuroimaging now allows for early diagnosis and has completely modified our knowledge on this disorder. CVT is more common than previously thought and it is recognised as a non-septic disorder with a wide spect...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 17  issue 1

pages  2- 2

publication date 2023-01

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023